Associate Professor
Psychiatry
Neurology
Email Website Contact Info More Publications
My clinical interests focus on the interface between psychiatry and movement disorders. Areas of interest include traditionally psychiatric movement disorders (including Huntington's disease, Tourette Syndrome, tardive dyskinesia, catatonia, motor signs in affective and psychotic disorders, and so-called psychogenic movement disorders) as well as psychological symptoms in traditionally neurologic movement disorders (e.g. Parkinson's disease, Sydenham's chorea, HD, and dystonia). Clinically I am especially interested in treatment and nosology. (See www.nil.wustl.edu/labs/movement/ for further information.)
My imaging research is influenced by these clinical interests and is primarily focused on functional imaging of the dopaminergic system. In many diseases (e.g. idiopathic dystonia, schizophrenia, REM sleep behavior disorder, TS) there is evidence for a functional abnormality of dopamine-influenced basal ganglia circuits, yet many studies of receptors or other specific elements of these pathways have been equivocal or negative. By giving a dopamine agonist, we "push on" these systems in a manner analogous to clinical challenge tests, and measure the response using PET and functional MRI methods. I have collaborated with Joel S. Perlmutter, M.D., Tamara Hershey, Ph.D., and others on studies of Parkinson's disease and idiopathic dystonia. I am now working on methods development with pharmacological fMRI (phMRI) and several studies of Tourette syndrome.
Research Publications
Black KJ, Hershey T, Koller JM, Videen TO, Mintun MA, Price JL, Perlmutter JS (2002 Dec 24). A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonist. Proc Natl Acad Sci U S A. 99 (26): 17113-8. Full Article >
Black KJ, Koller JM, Snyder AZ, Perlmutter JS (2004). Atlas template images for nonhuman primate neuroimaging: baboon and macaque. Methods Enzymol. 385: 91-102. Full Article >
Hershey T, Black KJ, Hartlein JM, Barch DM, Braver TS, Carl JL, Perlmutter JS (2004 May 1). Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot study. Biol Psychiatry. 55 (9): 916-25. Full Article >
Black KJ, Webb H (2001 Nov 12, updated 2006 Mar 22). Tourette syndrome and other tic disorders. eMedicine Journal. Full Article >
Black KJ, Hershey T, Hartlein JM, Carl JL, Perlmutter JS (2005 Mar). Levodopa challenge neuroimaging of levodopa-related mood fluctuations in Parkinson's disease. Neuropsychopharmacology. 30 (3): 590-601. Full Article >
Wang L, Lee DY, Bailey E, Hartlein JM, Gado MH, Miller MI, Black KJ (2007 Feb 28). Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndrome. Psychiatry Res. 154 (2): 181-90. Full Article >
Contact Info
Kevin Black, M.D.
Office Location: 2106 East Bldg.
Office Phone: 314-362-2469
Lab Phone: 314-362-6281
Campus Box: 8134
Fax: 314-362-0193
kevin@npg.wustl.edu
http://www.nil.wustl.edu/labs/kevin/kevin.htm
