Dr. Clifford has a broad interest in neuropharmacology. Development of more successful medical management of neurologic disease has been his clinical focus, and has included participation in studies of epilepsy, Parkinson's disease, multiple sclerosis, and virtually all neurologic complications of HIV. His present focus is on developing optimal treatments for neurologic complications of HIV including the HIV-associated dementia, painful peripheral neuropathies in HIV, progressive multifocal leukoencephalopathy, cryptococcal meningitis, toxoplasma encephalitis, primary CNS lymphoma, cytomegalovirus encephalitis/radiculomyelitis, and HIV myelopathy. Dr. Clifford leads a nationwide clinical research group, the Neurologic AIDS Research Consortium, funded by NINDS of the National Institute of Health, whose specific mission is to pursue better treatments for HIV associated neurologic complications.
Research Publications
Snyder MD, Storch GA, Clifford DB (2005 May 10). Atypical PML leading to a diagnosis of common variable immunodeficiency. Neurology. 64 (9): 1661. Full Article >
Lopate G, Pestronk A, Evans S, Li L, Clifford D (2005 May 10). Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy. Neurology. 64 (9): 1632-4. Full Article >
Clifford DB (2003). Challenges for clinical trials to treat progressive multifocal leukoencephalopathy. J Neurovirol. 9 Suppl 1: 68-72. Full Article >
Avasarala JR, Cross AH, Clifford DB, Singer BA, Siegel BA, Abbey EE (2003 Feb). Rapid onset mitoxantrone-induced cardiotoxicity in secondary progressive multiple sclerosis. Mult Scler. 9 (1): 59-62. Full Article >
Izumi Y, Benz AM, Katsuki H, Matsukawa M, Clifford DB, Zorumski CF (2003). Effects of fructose-1,6-bisphosphate on morphological and functional neuronal integrity in rat hippocampal slices during energy deprivation. Neuroscience. 116 (2): 465-75. Full Article >
Clifford DB, McArthur JC, Schifitto G, Kieburtz K, McDermott MP, Letendre S, Cohen BA, Marder K, Ellis RJ, Marra CM (2002 Nov 26). A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment. Neurology. 59 (10): 1568-73. Full Article >
Contact Info
David Clifford, M.D.
Office Location: 4511 Forest Park Blvd - Suite 308
Office Phone: 314-362-9731
Campus Box: 8111
Fax: 314-454-1378
cliffordd@neuro.wustl.edu
http://www.neuro.wustl.edu/narc
