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Ralph Dacey, M.D.
Professor and Head
Neurological Surgery
Neurological Surgery

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Our research centers on the cellular physiology of the cerebral microvasculature. We studythe role of radial and longitudinal cell to cell communication in microvascular regulation. Experimental studies focus on an examination of the heterogeneous responsiveness of isolated and cannulated intracerebral arterioles to vasoactive substances affecting the endothelial and smooth muscle cell layers of the vascular wall.

Research Publications

Horiuchi T, Dietrich HH, Hongo K, Dacey RG Jr (2003 Jun). Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. Stroke. 34 (6): 1473-8. Full Article >

Horiuchi T, Dietrich HH, Hongo K, Dacey RG Jr (2002 Nov). Mechanism of extracellular K+-induced local and conducted responses in cerebral penetrating arterioles. Stroke. 33 (11): 2692-9. Full Article >

Horiuchi T, Dietrich HH, Hongo K, Goto T, Dacey RG Jr (2002 Mar). Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis. Stroke. 33 (3): 844-9. Full Article >

Diringer MN, Videen TO, Yundt K, Zazulia AR, Aiyagari V, Dacey RG Jr, Grubb RL, Powers WJ (2002 Jan). Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury. J Neurosurg. 96 (1): 103-8. Full Article >

Horiuchi T, Dietrich HH, Tsugane S, Dacey RG Jr (2001 Feb). Analysis of purine- and pyrimidine-induced vascular responses in the isolated rat cerebral arteriole. Am J Physiol Heart Circ Physiol. 280 (2): H767-76. Full Article >

Horiuchi T, Dietrich HH, Tsugane S, Dacey RG Jr (2001 Jan). Role of potassium channels in regulation of brain arteriolar tone: comparison of cerebrum versus brain stem. Stroke. 32 (1): 218-24. Full Article >

Contact Info
Ralph Dacey, M.D.
Office Location: 5 McMillan Hosp.
Office Phone: 314-362-3571
Campus Box: 8057
Fax: 314-362-2107