The objective of the Ances laboratory is to: 1) characterize HIV associated neurocognitive
disorders (HAND) using calibrated blood oxygen level dependent functional magnetic
resonance imaging (BOLD fMRI); 2) assess the impact of combination antiretroviral therapy
(cART) on calibrated BOLD fMRI. This work will delineate associations between calibrated
BOLD fMRI and surrogate cerebral spinal fluid (CSF) markers of inflammation and neuronal/glial
injury. The ultimate goal is to create a non-invasive neuroimaging tool for early detection and
treatment of HAND.
Research Publications
Ances BM, Liang CL, Leontiev O, Perthen JE, Fleisher AS, Lansing AE, Buxton RB (2008 May 8). Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation. Hum Brain Mapp. Full Article >
Ances BM, Letendre SL, Alexander T, Ellis RJ (2008 Feb). Role of psychiatric medications as adjunct therapy in the treatment of HIV associated neurocognitive disorders. Int Rev Psychiatry. 20 (1): 89-93. Full Article >
Ances BM, Leontiev O, Perthen JE, Liang C, Lansing AE, Buxton RB (2008 Feb 15). Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI. Neuroimage. 39 (4): 1510-21. Full Article >
Roc AC, Ances BM, Chawla S, Korczykowski M, Wolf RL, Kolson DL, Detre JA, Poptani H (2007 Sep). Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy. Arch Neurol. 64 (9): 1249-57. Full Article >
Sanossian N, Ances BM, Shah SH, Kim D, Saver JL, Liebeskind DS (2007 Sep). FLAIR vascular hyperintensity may predict stroke after TIA. Clin Neurol Neurosurg. 109 (7): 617-9. Full Article >
Mowry EM, Woo JH, Ances BM (2007 Jun). Baló's concentric sclerosis presenting as a stroke-like syndrome. Nat Clin Pract Neurol. 3 (6): 349-54. Full Article >
Contact Info
Beau Ances, M.D., Ph.D.
bances@wustl.edu
