Associate Professor
Neurological Surgery
Cell Biology and Physiology
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Research in our laboratory is aimed at elucidating the mechanisms of vascular and neuronal protection against CNS ischemic injury by a process called hypoxic preconditioning, wherein exposure to sublethal hypoxia promotes the activation of an endogenous protective phenotype in these cells. We also study inflammatory and oxidative mechanisms of vascular and neuronal injury in brain and retina of genetically engineered mice using videomicroscopic and other methods to directly visualize these injury processes. Cerebral and retinal endothelial cell cultures are also used as concomitant in vitro models of ischemic injury and preconditioning-induced protection.
Research Publications
Gidday JM (2006 Jun). Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci. 7 (6): 437-48. Full Article >
Zhu Y, Ohlemiller KK, McMahan BK, Park TS, Gidday JM (2006 Jan). Constitutive nitric oxide synthase activity is required to trigger ischemic tolerance in mouse retina. Exp Eye Res. 82 (1): 153-63. Full Article >
Gidday JM, Gasche YG, Copin JC, Shah AR, Perez RS, Shapiro SD, Chan PH, Park TS (2005 Aug). Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol. 289 (2): H558-68. Full Article >
Zhang Y, Zhang X, Park TS, Gidday JM (2005 Jul). Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. J Cereb Blood Flow Metab. 25 (7): 868-77. Full Article >
Altay T, Gonzales ER, Park TS, Gidday JM (2004 Mar). Cerebrovascular inflammation after brief episodic hypoxia: modulation by neuronal and endothelial nitric oxide synthase. J Appl Physiol. 96 (3): 1223-30. Full Article >
Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR (2000 Sep). Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol. 48 (3): 285-96. Full Article >
Contact Info
Jeffrey Gidday, Ph.D.
Office Location: McDonnell Pediatric Research Bldg, 3rd floor
Office Phone: 286-2795
Lab Phone: 286-2785
Campus Box: 8057
Fax: 286-2900
gidday@nsurg.wustl.edu
http://neurosurgery.wustl.edu/giddayparklab.htm
