Our work uses short-lived (i.e., 2-110 minute half-life) cyclotron-produced, positron-emitting radionuclides with positron emission tomography (PET) and functional Magnetic Resonance Imaging (f MRI) for the in vivo study of the central nervous system of humans and non-human primates.
The research can be divided into two general categories: methods development and applications. In the area of methods development, we are concerned with the development and testing of mathematical models of blood flow, metabolism and pharmacology in in vivo systems. This work has ranged from strategies for the measurement of blood flow, blood volume, oxygen consumption, tissue pH and glucose utilization to receptor pharmacology. Most recently, we have been involved in investigations of image analysis strategies, including image averaging techniques, response localization in functional images and statistical analysis techniques. Applications involve studies in normal subjects using PET and fMRI to determine systems within the normal human brain concerned with specific cognitive and emotional functions. We are studying patients with psychiatric diseases such as depression and anxiety to determine the systems (language, memory, attention) responsible for the disease and the response of these systems to treatment.
Research Publications
Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME (2005 Jul 5). From The Cover: The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A. 102 (27): 9673-8. Full Article >
Fox MD, Snyder AZ, McAvoy MP, Barch DM, Raichle ME (2005 Apr 15). The BOLD onset transient: identification of novel functional differences in schizophrenia. Neuroimage. 25 (3): 771-82. Full Article >
Burton H, Snyder AZ, Raichle ME (2004 Oct 26). Default brain functionality in blind people. Proc Natl Acad Sci U S A. 101 (43): 15500-5. Full Article >
Kerr DL, Gusnard DA, Snyder AZ, Raichle ME (2004 Mar 22). Effect of practice on reading performance and brain function. Neuroreport. 15 (4): 607-10. Full Article >
Mintun MA, Vlassenko AG, Rundle MM, Raichle ME (2004 Jan 13). Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain. Proc Natl Acad Sci U S A. 101 (2): 659-64. Full Article >
Lustig C, Snyder AZ, Bhakta M, O'Brien KC, McAvoy M, Raichle ME, Morris JC, Buckner RL (2003 Nov 25). Functional deactivations: change with age and dementia of the Alzheimer type. Proc Natl Acad Sci U S A. 100 (24): 14504-9. Full Article >
Contact Info
Marcus Raichle, M.D.
Office Location: Biotechnology Bldg.
Office Phone: 314-362-6907
Campus Box: 8225
Fax: 314-362-6110
marc@npg.wustl.edu
