Welcome to the lab of Dr. Paul Shaw PhD




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The primary goal of my laboratory is to identify and describe molecular pathways that are relevant for our understanding of mammalian sleep and sleep homeostasis and to determine if these pathways impact motivated waking behaviors. Pathways are currently being identified by evaluating convergent data sets derived from traditional approaches (mutant screens and ion experiments) as well as the creative application of cDNA microarrays in the model organism Drosophila melanogaster. As candidate genes are identified, the corresponding mutants are studied to determine whether they form additive or epistatic interactions. More importantly, the behavior of mutant flies are evaluated in established learning paradigms to determine if alterations in sleep processes are associated with alterations in waking performance/plasticity.  candidate genes are subsequently evaluated to determine if they play a role in mammalian sleep using classic experimentation in the rodent.