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PRODID:-//Department of Neuroscience//NONSGML Events//EN
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UID:20250623T2027Z-1750710439.1215-EO-25368-1@10.73.10.87
STATUS:CONFIRMED
DTSTAMP:20260814T112049Z
CREATED:20250623T202434Z
LAST-MODIFIED:20260312T153531Z
DTSTART;TZID=America/Chicago:20260325T120000
DTEND;TZID=America/Chicago:20260325T130000
SUMMARY: Department of Neuroscience Seminar: Erika Holzbaur\, PhD (Penn)
DESCRIPTION: Erika Holzbaur\, PhD\, is giving a Department of Neuroscience 
 Seminar talk at WashU Medicine.
X-ALT-DESC;FMTTYPE=text/html: <h3><strong><span data-teams="true">Mechanism
 s locally regulating organelle dynamics in neurons</span><br /><img class="
 size-medium wp-image-25369 alignright" src="https://neuroscience.wustl.edu/
 app/uploads/2025/06/Erika-Holzbaur-245x300.jpg" alt="Erika Holzbaur is a wo
 man with long blonde hair." width="245" height="300" /></strong></h3><p sty
 le="font-weight: 400\;"><a href="https://www.med.upenn.edu/holzbaurlab/" ta
 rget="_blank" rel="noopener">Erika Holzbaur\, PhD</a><br />Professor\, Depa
 rtment of Physiology<br />Perelman School of Medicine<br />University of Pe
 nnsylvania<br />Director\, Pennsylvania Muscle Institute</p><p style="font-
 weight: 400\;">The Holzbaur Lab is focused on the microtubule-based motor c
 ytoplasmic dynein and its activator dynactin. Dynein and dynactin are requi
 red for vesicular trafficking\, mitotic spindle assembly and development of
  polarity. It is interested in mechanisms of force production and motor fun
 ction\, mechanisms of cargo coupling and regulation\, effects of dynein and
  dynactin on dynamics of the cytoskeleton\, and the analysis of neurodegene
 rative diseases resulting from impairments in dynein/dynactin function. Dis
 ruptions in dynein/dynactin function cause motor neuron degeneration and mu
 scle atrophy\, leading to motor neuron diseases similar to ALS. Approaches 
 in the lab include in vitro motility assays\, cellular transfection assays\
 , live cell microscopy and development and characterization of transgenic m
 ouse models for motor neuron disease.</p>
CATEGORIES:Seminar Series
LOCATION:Neuroscience Research Building Auditorium
GEO:38.635602;-90.254892
ORGANIZER;CN="Shea":MAILTO:shea.stewart@wustl.edu
URL;VALUE=URI:https://neuroscience.wustl.edu/events/event/department-of-neu
 roscience-seminar-erika-holzbaur/
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TZOFFSETFROM:-0600
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DTSTART:20260308T080000
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