BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Department of Neuroscience//NONSGML Events//EN
CALSCALE:GREGORIAN
X-ORIGINAL-URL:https://neuroscience.wustl.edu/events/
X-WR-CALDESC:Department of Neuroscience - Events
BEGIN:VEVENT
UID:20260810T1617Z-1786378622.167-EO-26193-1@10.73.15.224
STATUS:CONFIRMED
DTSTAMP:20260910T113258Z
CREATED:20260810T160033Z
LAST-MODIFIED:20260820T155822Z
DTSTART;TZID=America/Chicago:20260917T120000
DTEND;TZID=America/Chicago:20260917T130000
SUMMARY: Department of Neuroscience Seminar: Paola Arlotta (Harvard Univers
 ity)
DESCRIPTION: “Mammalian Brain Development and Disease: From Embryos to Orga
 noids” Paola Arlotta\, PhD Golub Family Professor of Stem Cell and Regenera
 tive Biology\, Harvard University Associate Member\, Stanley Center for Psy
 chiatric Research\, Broad Institute The function of the brain relies on the
  integration into functional circuits of an outstanding diversity of cell t
 ypes. Generation and maintenance of […]
X-ALT-DESC;FMTTYPE=text/html: <h3><strong>“Mammalian Brain Development and 
 Disease: From Embryos to Organoids”</strong></h3><p><a href="https://www.hs
 ci.harvard.edu/people/paola-arlotta-phd">Paola Arlotta\, PhD</a></p><p>Golu
 b Family Professor of Stem Cell and Regenerative Biology\, Harvard Universi
 ty<br />Associate Member\, Stanley Center for Psychiatric Research\, Broad 
 Institute<img class="size-medium wp-image-26195 alignright" src="https://ne
 uroscience.wustl.edu/app/uploads/2026/08/Screenshot-2026-08-10-110500-240x3
 00.png" alt="" width="240" height="300" /></p><p>The function of the brain 
 relies on the integration into functional circuits of an outstanding divers
 ity of cell types. Generation and maintenance of cell diversity\, correct w
 iring into neural circuits\, and orchestrated interaction of neurons and gl
 ia are critical\, and when disrupted lead to neurological disease.</p><p>Fo
 cusing on the developing cerebral cortex\, the Arlotta lab has had a long-s
 tanding interest in discovering the mechanistic principles that govern the 
 establishment and maintenance of cellular diversity and its integration int
 o working networks that subserve cortical function. While mice are instrume
 ntal for this basic work\, the cortex has diverged dramatically in primates
 \, and there is limited knowledge of development of the human cortex. Motiv
 ated by understanding how our own cortex develops and how human neurodevelo
 pmental disease emerges\, the lab has built on their basic program in the m
 ouse to instruct\, validate and study human cortical development in vitro\,
  within 3D cortical organoids of unprecedented complexity and reproducibili
 ty.</p><p>Collectively\, the Arlotta lab research program explores the inte
 rface between development and engineering of the neocortex\, to gain fundam
 ental understanding of both the principles that govern normal cortical deve
 lopment and of previously-inaccessible mechanisms of human neurodevelopment
 al disease.</p>
CATEGORIES:Seminar Series
LOCATION:Neuroscience Research Building Auditorium
GEO:38.635602;-90.254892
ORGANIZER;CN="Kristin Abraham":MAILTO:kristin.abraham@wustl.edu
URL;VALUE=URI:https://neuroscience.wustl.edu/events/event/department-of-neu
 roscience-seminar-paola-arlotta-harvard-university/
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
DTSTART:20260308T080000
TZNAME:CDT
END:DAYLIGHT
END:VTIMEZONE
END:VCALENDAR