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UID:20251107T2055Z-1762548904.5749-EO-25939-1@10.73.9.33
STATUS:CONFIRMED
DTSTAMP:20260804T140834Z
CREATED:20251107T204630Z
LAST-MODIFIED:20260205T145656Z
DTSTART;TZID=America/Chicago:20260401T120000
DTEND;TZID=America/Chicago:20260401T130000
SUMMARY: Department of Neuroscience Seminar: Steven Mennerick\, PhD (WashU 
 Medicine)
DESCRIPTION: Steven Mennerick\, PhD\, is giving a Department of Neuroscienc
 e Seminar talk at WashU Medicine.
X-ALT-DESC;FMTTYPE=text/html: <h3><strong>"Neurosteroids: Uses and Mechanis
 ms"</strong></h3><p><a href="https://sites.wustl.edu/mennericklab/">Steven 
 Mennerick\, PhD<img class="size-medium wp-image-25940 alignright" src="http
 s://neuroscience.wustl.edu/app/uploads/2025/11/Steven-Mennerick-245x300.jpg
 " alt="Steven Mennerick is a man with short gray and black hair and a black
  and gray beard. He wears glasses and a blue shirt." width="245" height="30
 0" /></a><br />Associate Dean of Graduate Education<br />Professor of Psych
 iatry and Neuroscience<br />John P. Feighner Professor of Neuropsychopharma
 cology<br />Scientific Director\, Taylor Family Institute for Innovative Ps
 ychiatric Research<br />WashU Medicine</p><p>Neurosteroids have emerged as 
 a novel class of therapeutics in neuropsychiatry\, particularly for postpar
 tum depression (PPD)\, where brexanolone and zuranolone represent landmark 
 FDA-approved treatments. These agents act as potent positive allosteric mod
 ulators (PAMs) of GABAA receptors\, with high efficacy and unique receptor 
 subtype selectivity. Broader applications require deeper mechanistic unders
 tanding\, which in turn requires new approaches. Recent studies integrating
  machine learning with medium-throughput biological screening have uncovere
 d new potential mechanisms of neurosteroid action. These findings suggest t
 hat neurosteroids may engage autophagy pathways\, exert anti-inflammatory e
 ffects and interact with GPCRs\, supporting their promise as multi-target t
 herapeutics. Innovative structures\, such as analogues suitable for DART an
 d for BIOTAC\, promise to reveal additional insights. Structural analogues 
 and cell-type selectivity may fine-tune receptor interactions and minimize 
 side effects. This translational narrative\, from endogenous steroid biolog
 y to clinical application\, underscores the importance of mechanistic insig
 ht in drug development and highlights opportunities for innovation in treat
 ing mood disorders.</p>
CATEGORIES:Seminar Series
LOCATION:Neuroscience Research Building Auditorium
GEO:38.635602;-90.254892
ORGANIZER;CN="Shea":MAILTO:shea.stewart@wustl.edu
URL;VALUE=URI:https://neuroscience.wustl.edu/events/event/department-of-neu
 roscience-seminar-steven-mennerick/
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