Tadashi Isa\, MD\, PhD
Professor
Division of Neurobiology and Physiology\,
Department of Neuroscience
\,
Graduate School of Medicine
in Kyoto University
What are unique to primates include (1) fine hand motor skill which is often affect ed by stroke or spinal cord injury\, and (2) high level cognition\, includi ng flexible decision making\, which is often affected in neuropsychiatric d isorders. Both of them are difficult to replicate in rodent models. During the past 2-3 decades\, our group has been working on the neural mechanisms of recovery of dexterous hand movements after partial spinal cord injury by applying multi-disciplinary approaches including electrophysiology\, neuro anatomy\, non-invasive brain imaging\, pharmacological intervention\, and c hemogenetic or optogenetic pathway-selective manipulation techniques with v iral vectors in macaque monkeys. Using these techniques\, we are also exten ding our research to understanding the neural mechanisms underlying visuomo tor systems preserved after damage to the primary visual cortex (blindsight )\, and flexible decision making based on motivation or risk preference. Fu rthermore\, we are applying our disciplines to understand the neural mechan isms of neuropsychiatric disorder phenotypes created by genome editing in m acaques. I will also talk about all these studies on nonhuman primates and also on the future perspectives of our studies.
CATEGORIES:Seminar Series ORGANIZER;CN="Liam Savage":MAILTO:liams@wustl.edu URL;VALUE=URI:https://neuroscience.wustl.edu/events/event/department-of-neu roscience-special-seminar-tadashi-isa-md-phd/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:STANDARD TZOFFSETFROM:-0500 TZOFFSETTO:-0600 DTSTART:20251102T070000 TZNAME:CST END:STANDARD END:VTIMEZONE END:VCALENDAR