Andreas Lüthi\, PhD
Senior Group Leader
Friedric
h Miescher Institute for Biomedical Research
Hosted by: Andreas Burkhalter\, PhD
This talk will be presented in-person an
d via Zoom.
Webinar link: https
://bit.ly/DoNSeminarSeries
Classical fear conditioning is one of the most powerful models for studying the neuronal substrates of associativ e learning and for investigating how plasticity in defined neuronal circuit s causes behavioral changes. In my talk\, I will focus on the organization and function of the neuronal circuitry of fear and discuss how functionally \, anatomically and genetically defined types of amygdala neurons contribut e to the acquisition and expression of conditioned fear behavior. Moreover\ , I will present recent experiments longitudinally imaging neural calcium d ynamics across different environments in freely moving mice engaged in expl oratory or instrumental behaviors demonstrating that changes in the activit y of major\, non-overlapping populations of amygdala principal neurons pred ict switches between behavioral states. The amygdala broadcasts state infor mation via several output pathways to larger brain networks\, and sensory r esponses in BA occur independently of behavioral state encoding. Thus\, the brain processes external stimuli and internal states orthogonally\, which may facilitate rapid and flexible selection of appropriate\, state-dependen t behavioral responses.
CATEGORIES:Seminar Series LOCATION:Moore Auditorium\, North Building GEO:38.634886;-90.261692 ORGANIZER;CN="Brian":MAILTO:bmarston@wustl.edu URL;VALUE=URI:https://neuroscience.wustl.edu/events/event/dynamic-encoding- of-behavioral-states-in-amygdala-circuits-andreas-luthi/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:DAYLIGHT TZOFFSETFROM:-0600 TZOFFSETTO:-0500 DTSTART:20220313T080000 TZNAME:CDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR