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UID:20210829T0235Z-1630204516.5787-EO-7660-1@172.23.128.19
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DTSTAMP:20260518T091217Z
CREATED:20210812T205630Z
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SUMMARY: Neuroimmune Interactions Shaping Social Behavior\, Gloria Choi\, P
 hD (Massachusetts Institute of Technology)
DESCRIPTION: Gloria Choi\, PhD\, is an associate professor in the Departmen
 t of Brain and Cognitive Sciences at The Picower Institute for Learning and
  Memory at the Massachusetts Institute of Technology.
X-ALT-DESC;FMTTYPE=text/html: <p><img class="alignright size-medium wp-imag
 e-7663" src="https://neuroscience.wustl.edu/app/uploads/2021/08/Headshot-Ch
 oi-300x300.jpeg" alt="gloria choi" width="300" height="300" /></p><p><a hre
 f="https://gloriachoi.org/" target="_blank" rel="noopener">Gloria Choi</a>\
 , PhD<br />Associate Professor<br />Department of Brain and Cognitive Scien
 ces<br />The Picower Institute for Learning and Memory<br />Massachusetts I
 nstitute of Technology</p><p><strong>Hosted by:</strong> Jason Yi</p><p>Vir
 tual event<br />Zoom webinar link: <a href="https://wustl.zoom.us/j/9515098
 9010" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" d
 ata-linkindex="0">https://wustl.zoom.us/j/95150989010</a></p><p>The benefic
 ial effects of infection and the ensuing inflammation on neurological disor
 ders have previously been noted. For example\, a subset of children with au
 tism spectrum disorder (ASD) exhibits temporary but considerable improvemen
 ts in their behavioral symptoms during episodes of fever\, a sign of system
 ic inflammation. However\, a mechanistic understanding of how fever-associa
 ted immune responses translate into behavioral relief—both at the molecular
  and neural level—is lacking.</p><p>We show that the social behavioral defi
 cits in offspring exposed to maternal immune activation can be temporarily 
 rescued by the inflammatory response elicited by the administration of lipo
 polysaccharide (LPS). This behavioral rescue was accompanied by a reduction
  in neural activity in the primary somatosensory cortex dysgranular zone (S
 1DZ)\, the hyperactivity of which has previously been implicated in the man
 ifestation of behavioral phenotypes associated with offspring exposed to MI
 A. We also show that both the behavioral rescue and the reduction in neural
  activity are mediated through the expression of IL-17 receptor subunit a (
 IL-17Ra) in the neurons of the S1DZ.</p><p><a href="https://neuroscience.wu
 stl.edu/news-events/events/">Return to events calendar »</a></p>
CATEGORIES:Seminar Series
ORGANIZER;CN="Brian":MAILTO:bmarston@wustl.edu
URL;VALUE=URI:https://neuroscience.wustl.edu/events/event/neuroimmune-inter
 actions-shaping-social-behavior-gloria-choi/
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