Postdoctoral Research Associate (Zhao lab)


Two positions are open in Dr. Guoyan Zhao’s laboratory in the Department of Neuroscience at Washington University School of Medicine (WUSM). The Zhao laboratory employs multiple cutting-edge technologies in genomics and computational biology to investigate the development and function of mammalian brains in the context of human health and disease. Current areas of interest include applying single-nucleus RNA-sequencing and spatial proteomics technologies on human brains with the goal of understanding disease pathogenesis of Alzheimer disease (AD), Parkinson disease (PD) and Lewy body diseases (LBDs).

The position requires working collaboratively with a team of experimental and computational biologists focused on single-nucleus RNA-seq data analysis and “multi-omics” data integration with a main goal to identify genetic markers and mechanisms of neurodegeneration that will lead to better disease diagnosis, treatment and eventually cure.  The candidate will be responsible for leading and carrying out these innovative projects, assist with grant preparation and reporting, and prepare and submit papers for publication. The candidate will have opportunities to travel and to present at national and international conferences.

The Department of Neuroscience is a highly collaborative and intellectually stimulating environment made up of over 30 international-leading faculty members. The neurodegenerative research program at WUSM is nationally and internationally recognized for its excellence and productivity. The Bioinformatics Program and the Neuroscience Program of WUSM is ranked #1 and #9 respectively by U.S. News and World report.

There is no better place to obtain training in bioinformatics and neuroscience than WUSM.

Career and professional development training for postdoctoral researchers is provided through the Office of Postdoctoral Affairs, Career Center, and many other groups. Additional information on being a postdoc at WUSM can be found at ( WUSM maintains a safe working environment through mandatory vaccine and mask requirements as of now.


This interdisciplinary research requires both biology/neuroscience and bioinformatics/statistics knowledge. Candidates with a PhD in Genetics, Neuroscience or a MD who would like to expand their skill set in the bioinformatics area, or candidates with a PhD in bioinformatics/computational biology/statistics who have a strong interest in neurodegeneration research are all welcome to apply. If you are an expert of both sides and would like to make impactful contributions to the neurodegeneration field, then this is a perfect position for you. Large-scale genomic data analysis is desirable but not required.

  1. Experience in large scale data analysis (e.g., RNA-seq, ChIP-seq or single cell RNA-seq) and relevant bioinformatics tools (e.g., Seurat, STAR, DESEQ2, etc.)
  2. Proficiency in scientific programming languages (e.g., Perl, Python, R), in a Linux/UNIX and/or Windows environment
  3. Knowledge or experience in molecular biology (neuroscience and neurodegeneration is a plus)
  4. Analytical, reasoning and problem-solving skills
  5. Highly motivated, well organized with excellent oral and written communication skills
  6. Ability to work independently, as well as part of a team, establishing and maintaining good working relationships with P.I. and other members of the research group

Interested candidates should send the following to

1) a cover letter explaining motivation, research experience and interests

2) CV

3) the names and contact information of three references

Job ID: JR62292