Yi Lab publishes study in Nature revealing molecular players in Angelman Syndrome

Researchers have shown in mice that slowed brain growth in Angelman’s syndrome is caused by elevated levels of a molecule called asparagine synthetase (green). NeuN (red), a marker for mature neurons, is stained here as well as a DAPI counterstain to show DNA (blue). Image courtesy Jason Yi.

Angelman Syndrome impacts roughly 1 in 20,000 births. It is a neuro-genetic disorder that impacts patients’ movement, sleep, and cognitive function. There is no cure for Angelman Syndrome, and often patients live as long as anyone else, but with far more difficulty due to the seizures, intellectual disability, and speech impairment (among other symptoms) caused […]

Han Lab publishes study revealing neuronal circuit for remembering rewarding places

Neuron cells imaged under a microscope in a wide array of colors against a black and white background.

Cognitive maps help us understand where we are, and remember how to navigate the world. For example, your brain (specifically, your hippocampus) has a map of your home – where tofind the kitchen, the bathroom, the bedroom, and so on. But it’s also important for your mental map to include the locations of things you […]

Build-up of common enzyme stunts brain growth (Links to an external site)

Image shows neurons expressing the molecule that is the central focus of this paper, called ASNS.

New research from Jason Yi, PhD, assistant professor of neuroscience at Washington University School of Medicine in St. Louis, has found in mice that the missing UBE3A gene is the first domino in a biological sequence that leads to a normally harmless enzyme accumulating in the brain. The buildup is not harmful on its own but appears to have indirect effects that ultimately impair brain growth.

Brain Development & Disorders Symposium – November 11, 2026

WashU faculty, trainees, researchers, and staff are invited to participate in the Brain Development & Disorders Symposium on Wednesday, November 11, 2026, from 8:00 a.m. to 6:00 p.m. in the Jeffrey T. Fort Neuroscience Research Building. This internal symposium will bring together investigators from WashU and invited speakers from institutions around the world to explore […]

Research soaring with the Eagles

Jason Yi is a man with short dark hair and wearing a tux. He is pictured with Swoop, the mascot of the Philadelphia Eagles.

Jason Yi, PhD, received a $400,000 pilot grant from the Eagles Autism Foundation to advance a new approach to treating autism spectrum disorder.