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Category: Research

Transcriptomic changes in glia linked to specific neurodegenerative diseases

March 2, 2023March 2, 2023
mmunohistochemistry staining of activated microglia in putamen of an individual with AD (microglia labeled by marker protein P2RY12, brown, and activation indicated by TREM2 transcripts, red)

A study of human brain tissue by Guoyan Zhao and colleagues identifies genetic activity in microglia and astrocytes related neurodegeneration and neuropathology among individuals with Alzheimer or Parkinson disease.

Cavalli Lab describes immune cells that promote nerve regeneration

February 10, 2023February 22, 2023
Dorsal root ganglion stained with TUJ1 (neuron, cyan) and IBA1 (macrophages, red)

After an injury to dorsal root ganglion neurons adjacent to the spinal cord, resident macrophages work with satellite glial cells to heal damaged axons.

Daily activity schedules mapped in the Drosophila brain

January 17, 2023March 6, 2023
Diagram illustrating the functional connections between circadian pacemaker neurons, downstream dopaminergic and neurosecretory centers, and daily behaviors

Cellular circuits downstream from circadian pacemaker neurons direct normal daily rhythms of feeding, mating and sleep.

Some dinos may have been as brainy as modern primates, controversial study argues (Links to an external site)

January 12, 2023March 6, 2023
Ashley Morhardt

Read Dr. Ashley Morhardt’s take on the paper in an article in Science.

Zebrafish advance as a model organism for Fragile X Syndrome

January 9, 2023March 6, 2023
A zebrafish with its nervous system fluorescently labeled in green and red hunts a paramecium, fluorescently labeled in green

A new study from the Goodhill Lab finds the genetic variant underlying an autism disorder causes changes in fish’s social behavior, preference in visual environment, and neural activity.

Glia: Unsung heroes of the nervous system (Links to an external site)

January 3, 2023March 6, 2023
Katie Lefton and gray Washington University shield logo

Read graduate student Katie Lefton’s article in Science Today about astrocytes, microglia, and satellite glial cells.

David Van Essen listed as Highly Cited Researcher for eighth consecutive year

December 9, 2022March 6, 2023
David Van Essen

Matthew Glasser, a former graduate student of Van Essen and currently an Instructor in Radiology, also made the 2022 list.

Taghert Lab identifies off switch for a set of circadian clock–controlled behaviors in flies

November 30, 2022February 22, 2023
microscope image of the Drosophila brain, fixed and double-stained for PDF (red fluorescence) and PDF-R (green fluorescense)

Phosphorylation of a receptor controls how messages from the neuropeptide PDF—which influence dawn and dusk activities in Drosophila—are curtailed on a daily basis to adapt the circadian clock to changing daylight.

Understanding, treating pain, reducing opioid use, aim of $11.7 million grant (Links to an external site)

November 4, 2022January 9, 2023
Pictured is a microscopic view of a human dorsal root ganglion. The nerve tissue is stained to reveal the cell bodies (in green) and axons (in red) of neurons that sense and transmit pain sensations.

Valeria Cavalli, PhD, and Guoyan Zhao, PhD, are among the collaborators at WashU participating in the Integrated Research Center for Human Pain Tissues (INTERCEPT) Pain Center at the School of Medicine.

People missing all or part of the connection between their brain hemispheres are more persuadable

October 28, 2022February 22, 2023
Brain tractography with connections colored red, green, blue and purple

A study of individuals with congenital corpus callosum dysgenesis suggests they face social difficulties due to being more easily influenced and less aware of being tricked.

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