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Science study identifies direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer

Science study identifies direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer (Links to an external site)

In a study published April 11 in Science, Adam Kepecs, PhD, and other WashU Medicine researchers report they discovered a previously unrecognized pathway in the brain that senses inflammation and actively suppresses dopamine — a key driver of motivation — resulting in apathy and loss of drive.
Case report shows how fluoxetine (Prozac) was repurposed to treat a severe seizure disorder in two sisters under treatment at WashU Medicine

Case report shows how fluoxetine (Prozac) was repurposed to treat a severe seizure disorder in two sisters under treatment at WashU Medicine (Links to an external site)

In Frontiers in Pharmacology, Lawrence Salkoff, PhD, and colleagues report how norfluoxetine, a long-lasting metabolite of fluoxetine that may accumulate in the brain at greater concentrations than fluoxetine itself in patients treated with fluoxetine, is most likely the agent bringing relief to the patients.