A recent study published in Immunity by the Li lab opens a new chapter for the study of microglial function in development and neurodegeneration with remarkable precision.
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Fluorescence lifetime imaging captures neuromodulator dynamics at multiple time scales
A new study from Yao Chen’s lab reveals that some fluorescent-intensity–based sensors also show fluorescence lifetime responses, expanding observations of neuromodulator activity over time and distance.
Key regulator of decision-making pinpointed in brain (Links to an external site)
Findings shed light on mental illnesses, including obsessive-compulsive disorder, anxiety
How does waste leave the brain? (Links to an external site)
Professor Krikor Dikranian and Assistant Professor Peter Bayguinov among authors of new study in Nature describing a route that serves as a passageway to clear fluid waste from brain.
Introducing a new conceptual framework for astrocyte function
In Nature Neuroscience, Thomas Papouin and colleagues describe the role of astrocytes in “contextual guidance.”
Sleep disruption—whether from loss of sleep or “social jet lag”—affects thermoregulation
Fruit flies seek out warmer temperatures when they experience sleep deprivation or fragmentation or when faced with a shifted sleep schedule, similar to when people stay up late and sleep in on the weekend.
How do developing brains assemble and organize themselves? (Links to an external site)
Brain areas are marked by distinct activity patterns very early, marsupial study published in PNAS by the Richards Lab shows.
Gabel Lab identifies molecular links between Sotos and Tatton Brown Rahman Syndromes
The two rare genetic diseases, which have striking phenotypic similarities, lead to similar downstream consequences on gene activity in neurons of mouse models.
Transcriptomic changes in glia linked to specific neurodegenerative diseases
A study of human brain tissue by Guoyan Zhao and colleagues identifies genetic activity in microglia and astrocytes related neurodegeneration and neuropathology among individuals with Alzheimer or Parkinson disease.
Cavalli Lab describes immune cells that promote nerve regeneration
After an injury to dorsal root ganglion neurons adjacent to the spinal cord, resident macrophages work with satellite glial cells to heal damaged axons.