O’Malley Lab
Intracellular GPCR signaling
The O’Malley Lab is interested in the molecular and cellular bases of neurological and neuropsychiatric disorders. In particular, the lab is interested in signal transduction pathways mediated by metabotropic glutamate receptors such as mGluR5. These receptors are widely expressed throughout the CNS and play important roles modulating neuronal excitability during brain and synapse development and in learning and memory.