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Category: Home page featured publication

Science study identifies direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer (Links to an external site)

April 16, 2025April 16, 2025
Graphic shows Immune-to-brain circuit drives apathy-like behavior in cancer cachexia.

In a study published April 11 in Science, Adam Kepecs, PhD, and other WashU Medicine researchers report they discovered a previously unrecognized pathway in the brain that senses inflammation and actively suppresses dopamine — a key driver of motivation — resulting in apathy and loss of drive.

Satellite glial cells promote regenerative growth in sensory neurons

June 9, 2021September 21, 2021
drawing of the sciatic nerve being injured with a zoom in on ppar alpha, phospholipids, fasn, and palmitic acid highlighted

In a new paper, Valeria Cavalli’s lab describes the key role of a relatively poorly studied type of glial cells, satellite glial cells (SGC), in nerve repair.

Department of Neuroscience

WashU Medicine

CB 8108

660 S. Euclid Ave.

St. Louis, MO 63110

314-362-3033

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