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Category: Featured publication

Li Lab study published in Immunity further explores microglial states (Links to an external site)

August 8, 2024November 4, 2024
Figure shows scRNA-seq analysis of PAMs and DAMs from the article paper An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination.

A recent study published in Immunity by the Li lab opens a new chapter for the study of microglial function in development and neurodegeneration with remarkable precision.

Fluorescence lifetime imaging captures neuromodulator dynamics at multiple time scales

March 19, 2024March 19, 2024
Summaries of intensity and fluorescence lifetime of GRABACh3.0 in different sleep-wake stages in one mouse across sensor expression time.

A new study from Yao Chen’s lab reveals that some fluorescent-intensity–based sensors also show fluorescence lifetime responses, expanding observations of neuromodulator activity over time and distance.

Key regulator of decision-making pinpointed in brain (Links to an external site)

February 23, 2024March 19, 2024
Woman sitting at a laptop with two illustrated question marks next to her head

Findings shed light on mental illnesses, including obsessive-compulsive disorder, anxiety

How does waste leave the brain? (Links to an external site)

February 8, 2024March 19, 2024
Researchers at Washington University School of Medicine in St. Louis have discovered an anatomical brain structure (in green) that allows fluid waste to leave the brain. In neuroinflammatory conditions in mice, immune cells use these routes to enter the brain.

Professor Krikor Dikranian and Assistant Professor Peter Bayguinov among authors of new study in Nature describing a route that serves as a passageway to clear fluid waste from brain.

Introducing a new conceptual framework for astrocyte function

October 19, 2023December 14, 2023
Thomas Papouin

In Nature Neuroscience, Thomas Papouin and colleagues describe the role of astrocytes in “contextual guidance.”

Sleep disruption—whether from loss of sleep or “social jet lag”—affects thermoregulation

September 25, 2023December 14, 2023
Paul Shaw sitting at his desk behind a rack of fruit fly tubes

Fruit flies seek out warmer temperatures when they experience sleep deprivation or fragmentation or when faced with a shifted sleep schedule, similar to when people stay up late and sleep in on the weekend.

How do developing brains assemble and organize themselves? (Links to an external site)

August 29, 2023October 18, 2023
Video of a wave of electrical activity passes over the visual area of the brain of a marsupial joey.

Brain areas are marked by distinct activity patterns very early, marsupial study published in PNAS by the Richards Lab shows.

Gabel Lab identifies molecular links between Sotos and Tatton Brown Rahman Syndromes

May 4, 2023December 14, 2023
Nicole Hamagami and Dennis Wu

The two rare genetic diseases, which have striking phenotypic similarities, lead to similar downstream consequences on gene activity in neurons of mouse models.

Transcriptomic changes in glia linked to specific neurodegenerative diseases

March 2, 2023December 14, 2023
mmunohistochemistry staining of activated microglia in putamen of an individual with AD (microglia labeled by marker protein P2RY12, brown, and activation indicated by TREM2 transcripts, red)

A study of human brain tissue by Guoyan Zhao and colleagues identifies genetic activity in microglia and astrocytes related neurodegeneration and neuropathology among individuals with Alzheimer or Parkinson disease.

Cavalli Lab describes immune cells that promote nerve regeneration

February 10, 2023December 14, 2023
Dorsal root ganglion stained with TUJ1 (neuron, cyan) and IBA1 (macrophages, red)

After an injury to dorsal root ganglion neurons adjacent to the spinal cord, resident macrophages work with satellite glial cells to heal damaged axons.

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Department of Neuroscience

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